HML export
HML, or Histoimmunogenetics Markup Language, is an XML data format designed for exchange of HLA gene related information. This format addresses NGS data exchange by refining the HML to conform to the proposed Minimum Information for Reporting Immunogenomic NGS Genotyping (MIRING) reporting guidelines (miring.immunogenomics.org). More background information can be found here.
The HML export of NGSengine contains all relevant information generated by NGSengine in compliance to the HML standards. At present, exports can be generated for HLA- and HLA related genes, whereas exports for KIR genes are not yet available. Prerequisites for HML exporting are:
- Exports can be generated for analyzed loci only
- Loci with insufficient result will not be exported
- Rejected loci will not be exported
Preparations to enable HML export
Set the ‘Laboratory Code’
Go to ‘File’ > ‘Preferences’ > ‘Laboratory’ and fill in the ‘Laboratory Code’:
One-time setup of the HML export settings
To enable creating HML exports, a one-time setup of the export preferences is necessary.
Go to 'File' > 'Preferences' > 'Exporting' > 'New' and choose 'HML version 1.0' for exporting:
Generating an HML export file
Once the export is made available, the actual export can be generated.
The file name of the export will be ‘projectName.hml.xml’ and can be found in the Export folder in the Project folder.
'File' > 'Custom export' > 'HML export'
