MICA and MICB typing by NGS
NGSgo-AmpX MICA, MICB includes amplification primers for whole-gene amplification of MICA and MICB. The kit also includes the GenDx-LongMix enzyme mastermix, and is compatible with NGSgo library preparation and analysis in NGSengine. Available as RUO.
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See specifications| Product | Status | Reactions | Catalog | |
|---|---|---|---|---|
NGSgo®-AmpX MICA, MICBComponentsNuclease free water |
RUO | 96 | 2341372 | Favorite |
The MHC Class I chain-related genes A (MICA) and B (MICB) are located on chromosome 6, close to HLA-B. MICA and MICB genes are similar in structure to HLA Class I, but they do not bind peptides and do not engage with the T-cell receptor. Instead they engage with an activating receptor, NKG2D, expressed on the surface of NK cells and certain T cells. This interaction stimulates the cytolytic activity and cytokine production of these cells, and thereby influences immunological responses.
Amplification coverage
In solid organ transplantation, anti-MICA antibodies have been found to be a risk factor for both acute and chronic rejection. In stem cell transplantation, MICA mismatching has been associated with graft-versus-host disease, relapse, and overall mortality. Different studies have reported conflicting results though, therefore the effect of MICA donor-recipient mismatching remains controversial. In disease association studies, certain MICA polymorphisms have shown to be associated with various diseases including ankylosing spondylitis, inflammatory bowel disease, and diabetes.
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