GenDx > GenDx Products > qPCR Chimerism Monitoring > HLA loss > HLA-KMR®

HLA-KMR®

HLA loss detection assays
Available as RUO

Benefits

  • Detect HLA loss
  • Co-developed with hospitals of Essen and Milano
  • 10 different HLA markers

Description

When relapse is detected after HLA-mismatched hematopoietic stem cell transplantation (HSCT), it is important to understand whether or not it is characterized by “HLA loss”, i.e. genomic loss of the mismatched HLA, as this has important implications for the appropriate treatment options. The HLA-KMR kit contains 10 markers to detect HLA loss relapse. The 10 genomic markers are all located within HLA genes and integrated in the KMRtype/KMRtrack and KMRengine workflow.  Available as RUO.

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11 Items

Product Status Reactions Catalog

HLA-KMR Core Kit

Components

KMR501
KMR502
KMR504
KMR505
KMR506
KMR511
KMR512
KMR520
KMR521
KMR522

 RUO 12 8344152 Favorite

HLA-KMR HLA-A KMR501-A

Components

KMR501

 RUO 12 8344342-501 Favorite

HLA-KMR HLA-A KMR502-A

Components

KMR502

 RUO 12 8344342-502 Favorite

HLA-KMR HLA-A KMR504-A

Components

KMR504

 RUO 12 8344342-504 Favorite

HLA-KMR HLA-A KMR505-A

Components

KMR505

 RUO 12 8344342-505 Favorite

HLA-KMR HLA-A KMR506-A

Components

KMR506

 RUO 12 8344342-506 Favorite

HLA-KMR HLA-C KMR511-C

Components

KMR511

 RUO 12 8344342-511 Favorite

HLA-KMR HLA-C KMR512-C

Components

KMR512

 RUO 12 8344342-512 Favorite

HLA-KMR HLA-DPB1 KMR520-DPB1

Components

KMR520

 RUO 12 8344342-520 Favorite

HLA-KMR HLA-DPB1 KMR521-DPB1

Components

KMR521

 RUO 12 8344342-521 Favorite

HLA-KMR DPB1 KMR522-DPB1

Components

KMR522

 RUO 12 8344342-522 Favorite

Specifications

The 10 HLA-KMR markers target some of the most frequent alleles of HLA-A, -C, and -DPB1, the loci that are most often mismatched in haploidentical and unrelated HSCT. An informative marker for HLA loss (i.e. specifically targeting an HLA allele present in the recipient but not in the donor) can be found for 70.3% of haploidentical and 66.4% matched unrelated recipient-donor pairs. These percentages are from European studies and therefore mainly represent the Caucasian population.

The HLA-KMR workflow

 

To be supplied by the user:

  • Pipettes and tips (hydrophobic filters)
  • Ice or cooling block
  • Optical 96-wells reactions plates
  • Eppendorf tubes
  • PCR tubes, strips or plates
  • Optical adhesive seals
  • Micro centrifuge
  • Microtiter plate centrifuge
  • Vortex
  • MilliQ water
  • Compatible qPCR machine

Downloads

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