HLA (mis)matching plays an important role in the outcome of a kidney transplantation. HLA matching has been focusing traditionally on the mature protein as displayed on the cell surface. However, recent evidence highlights the potential significance of HLA class I leader peptides. Leader peptides guide HLA proteins to the cell surface. Upon removal of the leader peptide from the precursor HLA protein, HLA class I leader peptides can be presented by HLA-E. Being exposed in HLA-E on the cell surface, HLA-derived leader peptides potentially impact transplant outcomes.
In this webinar, Emma Peereboom, PhD candidate at the Center for Translational Immunology, University Medical Center Utrecht, will explore the role of these leader peptides in T-cell-mediated rejection after kidney transplantation and their relationship to CMV serostatus.
